Role of dendritic cells in Th1/Th2 balance: A novel therapeutic target of allergic diseases

• Ohshima Yusei

• Yasutomi Motoko

• Omata Nemuko

• Mayumi Mitsufumi

抄録

Considerable evidence supports the role of dendritic cells (DC) in the pathogenesis of allergic diseases. Dendritic cells, as the most potent antigen-presenting cells (APC) for the induction of primary immune response to antigen, are deeply involved in the differentiation of naïve T cells into Th2 cells, thereby developing the development of allergic sensitization. After sensitization, DC may also function as a major APC to control the activation and clonal expansion of memory Th2 cells. In addition, DC are able to produce chemokines to recruit Th2 cells into inflammatory sites, indicating DC are important agents in various phases of allergic inflammation. Recently, we have demonstrated that monocyte chemotactic protein-1 not only regulates the homing of DC, but also modulates DC function. The present paper reviews the role of DC in the regulation of the Th2 response in allergic diseases and discusses the possibility of a new therapeutic strategy targeting chemokine-mediated regulation of DC function.<br>

収録刊行物

• Allergology International

  Allergology International 53 (3), 219-226, 2004

  一般社団法人日本アレルギー学会

キーワード

• dendritic cell
• monocyte chemotactic protein-1
• OX40 ligand
• regulatory T cells
• Th2

詳細情報

• CRID: 1390001204634430848
• NII論文ID: 130004476814
• NII論文ID: 10014175749
• NII書誌ID: AA11091750
• DOI: 10.1111/j.1440-1592.2004.00337.x
• COI: 1:CAS:528:DC%2BD2cXpsFSqsr8%3D
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893015311205?httpAccept=text/plain
• Web Site: https://api.elsevier.com/content/article/PII:S1323893015311205?httpAccept=text/xml
• Web Site: https://search.jamas.or.jp/link/ui/2006032968
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可