Human mast cell activation through Fc receptors and Toll-like receptors

• Okayama Yoshimichi

  Reaserch Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute

• Okumura Shigeru

  Reaserch Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute Department of Microbiology, Tokyo Dental College

• Tomita Hisashi

  Reaserch Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute

• Katayama Hiroko

  Reaserch Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute

• Yuki Keisuke

  Reaserch Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute

• Kagaya Shinji

  Reaserch Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute

• Kashiwakura Jun-ichi

  Reaserch Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute

• Saito Hirohisa

  Reaserch Unit for Allergy Transcriptome, Research Center for Allergy and Immunology, RIKEN Yokohama Institute Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo Dental College

抄録

Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studies in animal models indicate that mouse mast cells may play a protective role in host defense against bacteria through the production of tumor necrosis factor-α, mainly as a result of Toll-like receptor (TLR) 4- or CD48-mediated activation. Moreover, several recent observations in animal models have indicated that mast cells may also play a pivotal role in coordinating the early phases of autoimmune diseases, particularly those involving auto-antibodies. We recently identified functional TLR4 and FcγRI on human mast cells, in which their expression had been upregulated by interferon-γ. We compared each of the receptor-mediated gene expression profiles with the FcεRI-mediated gene expression profile using high-density oligonucleotide probe arrays and discovered that human mast cells may modulate the immune system in a receptor-specific manner.<br>

収録刊行物

• Allergology International

  Allergology International 53 (3), 227-233, 2004

  一般社団法人日本アレルギー学会

キーワード

• adaptive immunity
• FcεRI
• FcγRI
• GeneChip
• innate immunity
• mast cell
• Toll-like receptor 4

詳細情報

• CRID: 1390282679611140736
• NII論文ID: 130004476815
• NII論文ID: 10014175797
• NII書誌ID: AA11091750
• DOI: 10.1111/j.1440-1592.2004.00338.x
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893015311217?httpAccept=text/plain
• Web Site: https://api.elsevier.com/content/article/PII:S1323893015311217?httpAccept=text/xml
• Web Site: https://search.jamas.or.jp/link/ui/2006032969
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可