De Novo Bone Formation Using Bovine Collagen and Platelet-rich Plasma in Animals

• MURATA Masaru

  Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido

• ARISUE Makoto

  Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido

Abstract

Recently, pepsin-digested collagen (so-called atelocollagen) has been used for tissue engineering as one of the most useful scaffolds for bone formation. Its excellent biocompatibility, due to its biological characteristics such, as absorbable properties and low antigenicity, has elevated collagen to become a primary resource in medical applications. Platelet-rich plasma (PRP) is an autologous vehicle that delivers a highly concentrated dose of platelets containing osteopromotive factors, such as platelet-derived growth factor (PDGF), and transforming growth factor beta-1 and beta-2 (TGF-β1 and TGF-β2). These growth factors are thought to help to induce local mesenchymal and epithelial cells to migrate, divide, and increase collagen synthesis. In this paper, the characteristics of bovine collagen, PRP and animal studies using them for bone formation are reviewed.

Journal

• Journal of Hard Tissue Biology

  Journal of Hard Tissue Biology 13 (1), 18-23, 2004

  THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY

Keywords

• bone formation
• collagen
• platelet-rich plasma

Details

• CRID: 1390282679436487680
• NII Article ID: 130004848157
• NII Article ID: 10014213634
• NII Book ID: AA11074332
• DOI: 10.2485/jhtb.13.18
• ISSN: 1880828X
• ISSN: 13417649
• NDL BIB ID: 7238878
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7238878
• Web Site: https://search.jamas.or.jp/link/ui/2006100285
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed