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- OCHIAI Ryuji
- Biological Science Laboratories, Kao Corp.
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- JOKURA Hiroko
- Biological Science Laboratories, Kao Corp.
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- SUZUKI Atsushi
- Biological Science Laboratories, Kao Corp.
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- TOKIMITSU Ichiro
- Biological Science Laboratories, Kao Corp.
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- OHISHI Mitsuru
- Department of Geriatric Medicine, Osaka University Medical School
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- KOMAI Norio
- Department of Internal Medicine, Kawasaki Medical School
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- RAKUGI Hiromi
- Department of Geriatric Medicine, Osaka University Medical School
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- OGIHARA Toshio
- Department of Geriatric Medicine, Osaka University Medical School
書誌事項
- タイトル別名
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- <B>Green Coffee Bean Extract Improves Human Vasoreactivity</B>
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抄録
Our previous study revealed the antihypertensive effects of green coffee bean extract (GCE) ingestion in spontaneously hypertensive rats. We suggested that this antihypertensive action was due to the fact that GCE contains chlorogenic acid (CQA) as a major phenolic compound, and CQA in turn contains ferulic acid as a metabolic component that acts on nitric oxide (NO) derived from the vascular endothelium. In this study, the effects of GCE on blood vessels were evaluated in healthy males. The subjects were 20 healthy males with reduced vasodilation responses measured by strain gauge plethysmograms (SPG) to ischemic reactive hyperemia. Of the 20 subjects, 10 (mean age, 37.2 years) ingested a test drink containing GCE (CQA: 140 mg/day), and the other 10 (mean age, 34.8 years) ingested a placebo drink for 4 months. During the ingestion period, SPG, pulse wave velocity (PWV), and serum biochemical parameters were measured, and acceleration plethysmograms (APG) were taken. The reactive hyperemia ratio (RHR) in the test drink group began to increase after ingestion for 1 month and was significantly higher (p <0.05) than that in the placebo group after ingestion for 3 months and 4 months. In addition, after ingestion for 4 months, the test drink group showed a significant decrease (p <0.01) in the plasma total homocysteine level compared with the pre-ingestion level. However, there were no significant differences in PWV or APG between the test drink group and the placebo drink group. The improvement in RHR after ingestion of a drink containing GCE suggested an improvement in vasoreactivity by this component. (Hypertens Res 2004; 27: 731-737)
収録刊行物
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- Hypertension Research
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Hypertension Research 27 (10), 731-737, 2004
日本高血圧学会
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キーワード
詳細情報
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- CRID
- 1390282679696616832
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- NII論文ID
- 130004437142
- 10014224398
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- NII書誌ID
- AA10847079
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- COI
- 1:CAS:528:DC%2BD2MXhs1Wrtbg%3D
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- ISSN
- 13484214
- 09169636
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- PubMed
- 15785008
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可