Open-Configuration MR-Guided Microwave Thermocoagulation Therapy for Metastatic Liver Tumors from Breast Cancer

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  • Abe Hajime
    Division of General Surgery, Shiga University of Medical Science
  • Kurumi Yoshimasa
    Division of Digestive Surgery, Shiga University of Medical Science
  • Naka Shigeyuki
    Division of Digestive Surgery, Shiga University of Medical Science
  • Shiomi Hisanori
    Division of Digestive Surgery, Shiga University of Medical Science
  • Umeda Tomoko
    Division of General Surgery, Shiga University of Medical Science
  • Naitoh Hiroyuki
    Division of General Surgery, Shiga University of Medical Science
  • Endo Yoshihiro
    Division of Digestive Surgery, Shiga University of Medical Science
  • Hanasawa Kazuyoshi
    Division of General Surgery, Shiga University of Medical Science
  • Morikawa Shigehiro
    Department of Surgery, and Molecular Neuroscience Research Center, Shiga University of Medical Science
  • Tani Tohru
    Division of Digestive Surgery, Shiga University of Medical Science

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Abstract

Background: Liver metastases from breast cancer are associated with a poor prognosis, however, local control with microwave thermocoagulation therapy has been used in certain subgroups of these patients in the past decade. In this study, open-configuration magnetic resonance (MR) -guided microwave thermocoagulation therapy was used for metastatic liver tumors from breast cancer, and the efficacy of this treatment was assessed.<br>Methods: Between June 2000 and April 2004, we used MR-guided microwave thermocoagulation therapy on 11 nodules in 8 patients with metastatic liver tumors from breast cancer. The procedure was carried out under general anesthesia. A 0.5 T open-configuration MR system and a microwave coagulator were used. Near-real-time MR images and real-time temperature images were collected and displayed on the monitor. The MR-compatible thoracoscope was used and combined with MR imaging guidance. Navigation software, a 3D Slicer, was installed and customized.<br>Results: The customized navigation software displayed near-real-time MR images. The percutaneous puncture into the tumors was successful in all cases. No mortality or major complications occurred as a result of the procedures. Five of the 8 patients are alive with new metastatic foci with a mean observation period of 25.9 months.<br>Conclusions: We developed several devices to allow safe, easy, and accurate MR-guided microwave thermocoagulation therapy of liver tumors. Open-configuration MR-guided microwave thermocoagulation therapy appears to be a feasible method for tumor ablation of metastatic liver tumors from breast cancer.

Journal

  • Breast Cancer

    Breast Cancer 12 (1), 26-31, 2005

    The Japanese Breast Cancer Society

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