Inhibition of vascular endothelial growth factor (VEGF) in oral cancer cells by HIF-1 decoy

DOI Web Site 29 References
  • IMAI Mie
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University
  • ISHIBASHI Hiroaki
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University
  • KAWAMURA Ryuzo
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University
  • SHIRASUNA Kanemitsu
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Science, Kyushu University

Bibliographic Information

Other Title
  • Ｈｙｐｏｘｉａ‐ｉｎｄｕｃｉｂｌｅ　ｆａｃｔｏｒ‐１（ＨＩＦ‐１）デコイによる培養口腔癌細胞の血管内皮増殖因子産生抑制
  • Hypoxia inducible factor 1 HIF 1 デコイ ニ ヨル バイヨウ コウクウガン サイボウ ノ ケッカン ナイヒ ゾウショク インシ サンセイ ヨクセイ

Search this article

Abstract

Angiogenesis plays a critical role in the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic fac torsproduced by tumor cells, and its synthesis has been shown to be modulated through the activation of some transcription factors including HIF-1 induced by hypoxic condition. We transfected synthetic oligodeoxynucleo tides (ODNs) with consensus sequence for HIF-1 bind ing (HIF-1 decoy ODNs) into cultured cancer cells (SAS cells) using the hemagglutinating virus of Japan (HVJ)-liposome method. The hypoxia induced overexpression of VEGF in SAS cells could be apparently suppressed by the transfection of HIF-1 decoy ODNs. These results suggest that the HIF-1 decoy strategy would be effective for regulating tumor growth by reducing angiogenic ac tivityof cancer cells through HIF-1-mediated gene trans activations.

Journal

References(29)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top