Behcet Disease Presenting with Neurological Complications Immediately after Conversion from Conventional Cyclosporin A to Microemulsion Formulation
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- MITSUI Yoshiyuki
- Department of Neurology, Kinki University School of Medicine
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- MITSUI Manami
- Department of Neurology, Kinki University School of Medicine
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- URAKAMI Rika
- Department of Neurology, Kinki University School of Medicine
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- KIHARA Mikihiro
- Department of Neurology, Kinki University School of Medicine
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- TAKAHASHI Mitsuo
- Department of Neurology, Kinki University School of Medicine
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- KUSUNOKI Susumu
- Department of Neurology, Kinki University School of Medicine
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Abstract
A 53-year-old man with Behçet disease was treated with conventional cyclosporin A (CyA), because of refractory bilateral uveitis. Immediately following the conversion from conventional CyA to a microemulsion formulation, he presented with neurological complications. The neurological findings, pleocytosis of the cerebrospinal fluid (CSF) and brainstem lesions revealed by brain magnetic resonance imaging (MRI) suggested neuro-Behçet disease. After discontinuing CyA and introducing oral prednisolone, the neurological symptoms, pleocytosis of CSF and brainstem lesions on MRI improved. Although the microemulsion formulation, which can maintain a stable level of blood CyA, is a useful agent for the control of ocular lesions in Behçet disease, the resulting abrupt increase in blood CyA level may have induced neuro-Behçet disease.
Journal
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- Internal Medicine
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Internal Medicine 44 (2), 149-152, 2005
The Japanese Society of Internal Medicine
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Details 詳細情報について
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- CRID
- 1390282679846034560
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- NII Article ID
- 10014377660
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- NII Book ID
- AA10827774
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- ISSN
- 13497235
- 09182918
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- NDL BIB ID
- 7248737
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- PubMed
- 15750277
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed