Chromosome Aberrations Induced by High-LET Radiations
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- Kawata Tetsuya
- Department of Radiology, Graduate School of Medicine, Chiba University, tkawata@faculty.chiba-u.jp
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- Ito Hisao
- Department of Radiology, Graduate School of Medicine, Chiba University
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- George Kerry
- NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory
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- Wu Honglu
- NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory
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- Cucinotta Francis A.
- NASA Lyndon B. Johnson Space Center, Radiation Biophysics Laboratory
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- Cucinotta F A
- NASA JSC
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Abstract
Measurements of chromosome aberrations in peripheral blood lymphocytes are currently the most sensitive and reliable indicator of radiation exposure that can be used for biological dosimetry. This technique has been implemented recently to study radiation exposures incurred by astronauts during space flight, where a significant proportion of the dose is delivered by high-LET particle exposure. Traditional methods for the assessing of cytogenetic damage in mitotic cells collected at one time point after exposure may not be suitable for measuring high-LET radiation effects due to the drastic cell cycle perturbations and interphase cell death induced by this type of exposure. In this manuscript we review the recent advances in methodology used to study high-LET induced cytogenetic effects and evaluate the use of chemically-induced Premature Chromosome Condensation (PCC) as an alternative to metaphase analysis. Published data on the cytogenetic effects of in vitro exposures of high-LET radiation is reviewed, along with biodosimetry results from astronauts after short or long space missions.
Journal
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- Biological Sciences in Space
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Biological Sciences in Space 18 (4), 216-223, 2004
Japanese Society for Biological Sciences in Space
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Keywords
Details 詳細情報について
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- CRID
- 1390001204431906048
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- NII Article ID
- 10014460942
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- NII Book ID
- AN10164806
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- COI
- 1:STN:280:DC%2BD2M3ksFKktg%3D%3D
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- ISSN
- 1349967X
- 09149201
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- NDL BIB ID
- 7289137
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- PubMed
- 15858388
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed