β２ミクログロブリンのアミロイド線維の構造と形成機構

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タイトル別名
  • Structure and Formation of Amyloid Fibrils of .BETA.2-Microglobulin
  • ベータ 2 ミクログロブリン ノ アミロイド センイ ノ コウゾウ ト ケイセイ キコウ

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抄録

Amyloid fibril formation is a phenomenon common to many proteins and peptides. Clarifying the mechanism of amyloid fibril formation is essential not only for understanding the pathogenesis of amyloidosis but also for improving our understanding of the mechanism of protein folding. Dialysis-related amyloidosis is a common and serious complication among patients on long-term hemodialysis, in which β2-microglobulin forms amyloid fibrils. We studied the core of fibrils at single-residue resolution using recently developed H/D exchange method with the dissolution of fibrils by dimethylsulfoxide. The results suggest the mechanism of amyloid fibril formation, in which the core β-sheet formed by a minimal sequence propagates to form a rigid and extensive β-sheet network.<br>

収録刊行物

  • 生物物理

    生物物理 44 (5), 212-217, 2004

    一般社団法人 日本生物物理学会

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