AmphotericinBの血中および臓器内濃度の実験的検討

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タイトル別名
  • EXPERIMENTAL STUDIES ON THE AMPHOTERICIN B CONTENT IN THE BLOOD AND VARIOUS ORGANS BY INTRAVENOUS AND ORAL ADMINISTRATIONS
  • Amphotericin B ノ ケッチュウ オヨビ ゾウキ ナイ ノウド ノ ジッケンテキ ケントウ

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In an attempt to investigate in detail the am photericin B content in the blood and various organs by intravenous and oral administrations, experiments using rabbits and the test strain, Candida albicans C-a-13 were performed and the following results were obtained.<BR>A standard in vitro inhibition curve of amphotericin B against the growth of the test strain was obtained using the semisynthetic medium in terms of turbidity by means of electrophotometer. Based, on this curve, the antibiotic content in the blood and organs was determined as follows.<BR>When administered the antibiotic at the rate of 1 mg/kg intravenously into the rabbits, the blood content reached the maximum of 2. 5 mcg/ml which exceeded the minimum inhibitory concentration in vitro, after 4 hours, henceforth keeping the level of around 1 mcg/ml for 10 hours long, and as to the content in the organs, the spleen was the highest in about 1. 5 mcg/g, came next the lung and kidney and the liver the lowest in the same grade.<BR>In case of oral administration of the drug at the rate of 50: mg/kg, the blood level reached the maximum of O. 4 mcg/ml after 3-6 hours, reducing very slowly.<BR>These results suggest that the intravenous administr ation of amphotericin B would be much more effective than its oral administration in systemic mycoses; however, in case of the latter application. its curative efficacy could not be always denied in view of maintenance of its partial inhibitory concentration in the blood for a relatively long period even by a single application.

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