ｃ‐ｋｉｔ遺伝子ｅｘｏｎ　９に変異を認めたメシル酸イマチニブ耐性腸間膜ｇａｓｔｒｏｉｎｔｅｓｔｉｎａｌ　ｓｔｒｏｍａｌ　ｔｕｍｏｒの１例

DOI Web Site 被引用文献3件 参考文献16件

書誌事項

タイトル別名
  • A Case of Imatinib Mesylate-Resistant Gastrointestinal Stromal Tumor Arisen in the Mesentery Having Mutation at Exon 9 of the c-kit Gene

この論文をさがす

抄録

We report an imatinib mesylate-resistant gastrointestinal stromal tumor (GIST) arising in the mesentery analyzed byc-kitmutation. A 58-year-old man examined for abdominal distension on July 27, 2002, was hospitalized on September 6, 2002, for a huge tumor in the hypogastric region detected by CT. The patient underwent resection of the mesenterial tumor, right hemicolectomy, and enterectomy on September 12, 2002. Histopathologically, the tumor was composed of a fascicular proliferation of spindle-shaped cells with marked mitosis. Immunohistochemically, tumor cells were positive forc-kitbut negative for CD34, actin, and s-100. The tumor was diagnosed as malignant GIST arising in the mesentery. Treatment with imatinib mesylate at a dose of 400 mg/day was initiated on October 27, 2002. CT showed multiple tumors on April 4, 2003. The patient underwent tumor resection again on April 23, 2003. Treatment with imatinib mesylate at a dose of 400mg/day was resumed on May 16, 2003, but on December 12, 2003, CT showed multiple tumors. The patient underwent further tumor resection on December 24, 2003. We suspected this case was imatinib mesylate-resistant GIST and analyzedc-kitmutation by using direct sequencing. A 6 base-pair insertion (GCC TAT) was found atc-kitexon 9 between codons 503 and 504. This case suggests that analysis of thec-kitmutation may be usefull as a prognostic factor and the evaluation of the effect of imatinib mesylate.

収録刊行物

被引用文献 (3)*注記

もっと見る

参考文献 (16)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ