Molecular mechanism for production of reactive oxygen species by neutrophils

• Miyano Kei

  Medical institute of bioregulation, Kyushu university

• Tamura Minoru

  Department of applied chemistry, Faculty of engineering, Ehime university

• Sumimoto Hideki

  Medical institute of bioregulation, Kyushu university

Bibliographic Information

Other Title

• 好中球による活性酸素生成の分子メカニズム

Abstract

Neutrophils, a member of leukocytes, phagocytose and kill phathogenic organisms, thereby playing a crucial role in host defense. During phagocytosis, an enzyme called the phagocyte NADPH oxidase becomes activated to produce reactive oxygen species (ROS) that act as microbicidal agents. Activation of the oxidase must be strictly regulated, since ROS have a high reactivity and thus their overproduction causes inflammatory responses. The oxidase activation involves assembly of the cytosolic regulatory proteins p47^phox, p67^phox, p40^phox, and small GTPase Rac with the membrane-integrated cytochrome b₅₅₈, the catalytic core of the enzyme. Because the assembly requires a variety of protein-protein interactions mediated via modular domains, the knowledge of regulation of these interactions is important for our understanding of the molecular mechanism for the NADPH oxidase activation. On the basis of our current findings, here we discuss the activation mechanism with special attention to the induction and maintenance of the interactions between the oxidase factors.

Journal

• Ensho Saisei

  Ensho Saisei 25 (2), 113-117, 2005

  The Japanese Society of Inflammation and Regeneration

Keywords

• NADPH oxidase
• reactive oxygen species
• neutrophil

Details

• CRID: 1390282680155680896
• NII Article ID: 10015450048
• NII Book ID: AA11508953
• DOI: 10.2492/jsir.25.113
• ISSN: 18805795
• ISSN: 13468022
• Web Site: https://search.jamas.or.jp/link/ui/2005149122
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed