Iminium Alkaloids from Marine Invertebrates: Structure, Biological Activity, and Biogenesis

• Kita Masaki

  Research Center for Materials Science, Nagoya University

• Uemura Daisuke

  Department of Chemistry, Graduate School of Science, Nagoya University

抄録

The discovery of new natural products frequently triggers a breakthrough in basic sciences. This review features marine iminium alkaloids, which control biologically and physiologically intriguing phenomena. Pinnatoxins, potent shellfish poisons purified from the Okinawan bivalve Pinna muricata, activate Ca²⁺ channels. Norzoanthamine hydrochloride, isolated from the colonial zoanthid Zoanthus sp., suppresses decreases in bone weight and strength in ovariectomized mice. Symbioimine, an amphoteric iminium metabolite from the dinoflagellate Symbiodinium sp., inhibits osteoclast differentiation. The latter two compounds are good candidates for antiosteoporotic drugs.

収録刊行物

• Chemistry Letters

  Chemistry Letters 34 (4), 454-459, 2005

  公益社団法人 日本化学会

キーワード

• General Chemistry

詳細情報

• CRID: 1390001204582107520
• NII論文ID: 10015514686
• NII書誌ID: AA00603318
• DOI: 10.1246/cl.2005.454
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/34/4/454/55586963/cl.2005.454.pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可