Diagnosis of Thyroid Follicular Carcinoma by the Vascular Pattern and Velocimetric Parameters Using High Resolution Pulsed and Power Doppler Ultrasonography
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- MIYAKAWA Megumi
- Department of Internal Medicine, Endocrine Center Toranomon Hospital
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- ONODA Noritaka
- Department of Internal Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
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- ETOH Miyuki
- Department of Internal Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
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- FUKUDA Izumi
- Department of Internal Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
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- TAKANO Kazue
- Department of Internal Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical University
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- OKAMOTO Takahiro
- Department of Surgery, Institute of Clinical Endocrinology, Tokyo Women's Medical University
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- OBARA Takao
- Department of Surgery, Institute of Clinical Endocrinology, Tokyo Women's Medical University
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抄録
The aim of this study was to define the preoperative diagnosis of thyroid follicular carcinoma by the vascular pattern and velocimetric parameters using high resolution pulsed and power Doppler ultrasonography (US). We compared the vascular pattern and the velocimetric parameters, such as peak systolic velocity (Vmax), end-diastolic velocity (Vmin), pulsatility index (PI), or resistance index (RI) between follicular adenoma (FA, n = 25) and follicular carcinoma (FC, n = 10) and analysed them by means of receiver characteristics curves (ROC). Of 10 patients with FC, 8 (80%) patients presented a moderate increase of intranodular vascularization using power Doppler US. In contrast, the majority (84%, 21 out of 25 cases) of FA cases showed only a peripheral rim of color flow even by power Doppler US. These color flow imagings by power Doppler US were suggested to be a reliable tool for the differential diagnosis of thyroid follicular tumor with a sensitivity of 87.5% and a specificity of 92%. In velocimetric analyses, the Vmax/Vmin ratios, PI, and RI were significantly higher in the patients with FC than those with FA (p<0.001, p<0.005, and p<0.001, respectively). By means of ROC, FC could be diagnosed with a cutoff value of ratio of PI (>1.35), RI (>0.78), and Vmax/Vmin (>3.79). The diagnostic efficiency evaluated by ROC curves were 0.898 for PI, 0.876 for RI, and 0.888 for Vmax/Vmin, respectively. In conclusion, the evaluation of the vascular pattern and the velocimetric parameters using pulsed and power Doppler ultrasound may provide important information that is useful in making correct differential diagnosis of malignant or benign thyroid follicular tumor preoperatively.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 52 (2), 207-212, 2005
一般社団法人 日本内分泌学会
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詳細情報
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- CRID
- 1390001206300287872
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- NII論文ID
- 10015549066
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- NII書誌ID
- AA10901436
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- ISSN
- 13484540
- 09188959
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- PubMed
- 15863949
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可