The effect of .ALPHA.2-adrenergic receptor agonist, dexmedetomidine, on tetrodotoxin resistant Na+ currents in small-sized dorsal root ganglion neurons

DOI 19 References
  • Maruyama Miyuki
    Department of Anesthesiology, Kitasato University School of Medicine
  • Okamoto Hirotsugu
    Department of Anesthesiology, Kitasato University School of Medicine
  • Nakano Takaaki
    Department of Anesthesiology, Kitasato University School of Medicine
  • Kimotsuki Hiroshi
    Department of Anesthesiology, Kitasato University School of Medicine
  • Hoka Sumio
    Department of Anesthesiology, Kitasato University School of Medicine

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Abstract

We examined the effects of α2-adrenergic agonist, dexmedetomidine(DEX), on tetrodotoxin-resistant (TTX-r) Na+ currents using small-sized dorsal root ganglion(DRG) cells of the rats. Whole cell patch-clamp configuration was used. After control Na+ current was recorded, DEX was added to the extracellular solution. Yohimbine and prazosin were used to differentiate the contribution of α2-adrenergic receptor from that of α1-adrenergic receptor. The peak TTX-r Na+ currents were significantly and dose dependently inhibited by DEX(p<0.05). Yohimbine attenuated the suppressive effects of DEX on TTX-r Na+ currents, while prazosin did not alter the effects of DEX. Thus, DEX inhibited TTX-r Na+ currents by way of α2-adrenergic receptors but not α1-adrenergic receptors. Therefore, it is suggested that DEX has an inhibitory effect on TTX-r Na+ channels through α2-adrenergic receptors.

Journal

  • CIRCULATION CONTROL

    CIRCULATION CONTROL 26 (1), 24-28, 2005

    Japan Society of Circulation Control in Medicine

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