A Patient with TP53 Germline Mutation Developed Bowen's Disease and Myelodysplastic Syndrome with Myelofibrosis after Chemotherapy against Ovarian Cancer
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- KURIBAYASHI Kageaki
- 4th Department of Internal Medicine
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- MATSUNAGA Takuya
- 4th Department of Internal Medicine
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- SAKAI Toshio
- 4th Department of Internal Medicine
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- WADA Yuko
- 4th Department of Internal Medicine
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- TATENO Kumiko
- 4th Department of Internal Medicine
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- MURASE Kazuyuki
- 4th Department of Internal Medicine
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- FUJIMI Akihito
- 4th Department of Internal Medicine
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- TAKIMOTO Rishu
- 4th Department of Internal Medicine
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- TERUI Takeshi
- 4th Department of Internal Medicine
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- KATO Junji
- 4th Department of Internal Medicine
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- SASAKI Aya
- Clinical Pathology, Sapporo Medical University School of Medicine
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- SATOH Masaaki
- Clinical Pathology, Sapporo Medical University School of Medicine
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- NIITSU Yoshiro
- 4th Department of Internal Medicine
Bibliographic Information
- Other Title
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- Patient with TP53 Germline Mutation Developed Bowen s Disease and Myelodysplastic Syndrome with Myelofibrosis after Chemotherapy against Ovarian Cancer
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Abstract
Here we report a case of myelodysplastic syndrome (MDS) with myelofibrosis associated with Bowen’s disease. A female patient had undergone an operation and chemotherapy for ovarian cancer when she was 65 years old, and she developed MDS at the age of 70 years old. PCR-single strand conformation polymorphism (SSCP) analysis of peripheral blood mononuclear cells, a Bowen’s disease lesion, and normal skin showed an abnormal peak in TP53 exon5. Direct sequencing revealed that they all had missense mutation in codon 175 (G to A) of arginine switched to histidine, suggesting a germline mutation of TP53. It was speculated that p53 function was lost by TP53 germline mutation with the loss of a wild type allele induced by the chemotherapy against ovarian cancer, leading to the development of MDS. No therapeutic effects of low dose melphalan or cyclosporine A on MDS were observed, however one month of 30 mg/day prednisolone administration induced a hematological response.
Journal
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- Internal Medicine
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Internal Medicine 44 (5), 490-495, 2005
The Japanese Society of Internal Medicine
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Details 詳細情報について
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- CRID
- 1390001204867071616
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- NII Article ID
- 10015651061
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- NII Book ID
- AA10827774
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- ISSN
- 13497235
- 09182918
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- NDL BIB ID
- 7318396
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- PubMed
- 15942101
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed