Regeneration of salivary gland by use of growth factors and cultured salivary gland cells

• KAGAMI Hideaki

  Department of Tissue Engineering, Nagoya University School of Medicine

• SUGITO Takayuki

  Department of Tissue Engineering, Nagoya University School of Medicine Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

• UEDA Minoru

  Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine Division of Stem Cell Engineering, Tooth Regeneration, The Institute of Medical Science, The University of Tokyo

Bibliographic Information

Other Title

• 増殖因子および培養細胞を用いた唾液腺の再生
• ゾウショク インシ オヨビ バイヨウ サイボウ オ モチイタ ダエキセン ノ サイセイ

Abstract

Salivary gland dysfunction is not only a common inter estin the field of oral medicine but also an important clinical consideration for general dentistry. Hyposaliva tionaffects various oral conditions including dental caries, denture problems and oral discomfort. Medications such as pirocarpine and sevemelin hydrochloride can induce salivation from the residual tissue and temporar ilyrelieve patients' symptoms. However, there is no treatment to repair the damaged salivary gland. Recently, new technology-based treatments such as tissue engineering or (stem) cell therapy have been reported by use of autologous or allogenic cells in several fields. These technologies utilize cells to rebuild, restore or regenerate damaged tissue and have been successfully applied for patients with severe burns, cartilage defects and cardiovascular tissue replacement. Furthermore, growth factors have been used in clinics to induce tis sueregeneration in cases of delayed wound healing or to accelerate organ regeneration. Unlike the medications used for dry mouth patients, these new technologies have the potential to regenerate the damaged organ or tissue itself. In terms of the salivary gland, there is no treatment to repair an atrophic or damaged gland at present. However, there have been an increasing number of studies which may lead to such new treatments. In this review, the possibility of cell therapy and growth factor therapy for the salivary gland are discussed.

Journal

• Journal of The Japanese Stomatological Society

  Journal of The Japanese Stomatological Society 54 (2), 211-215, 2005

  Japanese Stomatological Society

Keywords

• Salivary gland
• regenerative medicine
• cell transplantation
• growth factor

Details

• CRID: 1390001206436262912
• NII Article ID: 10015656532
• NII Article ID: 130004114504
• NII Book ID: AN00189050
• DOI: 10.11277/stomatology1952.54.211
• ISSN: 21850461
• ISSN: 00290297
• NDL BIB ID: 7493354
• Web Site: http://id.ndl.go.jp/bib/7493354
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7493354
• Web Site: https://search.jamas.or.jp/link/ui/2005137788
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed