Treatment of Arthritis in Psoriasis Arthropathica with Oral Salazosulfapyridine

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  • 関節症性乾癬の関節痛に対する治療の検討―サラゾスルファピリジン療法の試み―
  • カンセツショウセイカンセン ノ カンセツツウ ニ タイスル チリョウ ノ ケントウ サラゾスルファピリジン リョウホウ ノ ココロミ

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Abstract

Psoriasis arthropathica (PA) accounts for about 2～7% of total psoriasis patients, and it is often difficult to treat the associated arthritis. In this study, we epidemiologically evaluated the efficacy of variable treatments for arthralgia in patients with PA in our outpatient department during the past eight years. Our results found that our 25 patients (15 men and 10 women) had been treated with several drugs. Efficacy was reported in 60.0% patients treated with cyclosporin, 50.0% with acemetacin, 40.0% with diclofenac sodium, 31.6% with loxoprofen sodinm and 42.9% with prednisolone. The eight patients who did not show alleviation of arthralgia after treatment with the above-mentioned drugs, were treated with salazosulfapyridine. In six out of these eight cases, almost complete remission of arthralgia was achieved 8–15 weeks after the initiation of administration; nausea occurred in one case soon after the start of administration, and no response was seen in the other case. These results indicated that salazosulfapyridine can be one of the therapeutic options for arthralgia in PA patients that show resistance to various other types of other treatment.

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