書誌事項
- タイトル別名
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- Biological differences between lymphocytes from thymomas and from thymuses containing thymomas in myasthenia gravis patients.
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抄録
Lymphocytes separated from thymoma (TLY) of myasthenia gravis (MG) patients were examined for their abilities to develop natural killer (NK) and lymphokine-activated killer (LAK) activities when stimulated by interleukin 2 (IL-2) and their phenotypic changes during activation with IL-2. Lymphocytes separated from non-thymomatous tissues of thymuses containing thymomas (NTLY) and peripheral blood lymphocytes (BLY) of MG patients were also examined for their abilities to develop NK and LAK activities and their phenotypic changes during activation. TLY of all MG patients developed LAK activity in response to incubation with recombinant IL-2 for 4 days. TLY of six of these seven patients also developed cytolytic activity against K 562 target cells. BLY of all of the patientts developed cytolytic activity against K 562 and LAK activity when incubated for 4 days with IL-2. The proportions of CD rcells and CD 25+ cells of TLY and NTLY of the MG patients increased significantly during incubation with IL-2 (P <0.05, P P<0.01, P<0.05). Although there was no significant phenotypic difference between TLY and NTLY of MG patients. LAK activity developed by TLY was significantly higher than that developed by NTLY (P<0.05).<BR>These results indicate that the TLY of MG patients differs functionally from the NTLY of MG patiens.
収録刊行物
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- 日本呼吸器外科学会雑誌
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日本呼吸器外科学会雑誌 10 (6), 646-650, 1996
特定非営利活動法人 日本呼吸器外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001204360750208
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- NII論文ID
- 10016101927
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- NII書誌ID
- AN10467885
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- ISSN
- 18814158
- 09190945
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可