Glutamatergic Chemical Transmission: Look! Here, There, and Anywhere

• Moriyama Yoshinori

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University

• Yamamoto Akitsugu

  Department of Bio-Science, Faculty of Bio-Science, Nagahama Institute of Bio-Science and Technology

抄録

Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT 1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone-containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action.

収録刊行物

• The Journal of Biochemistry

  The Journal of Biochemistry 135 (2), 155-163, 2004

  社団法人 日本生化学会

キーワード

• acrosome
• BNPI
• chemical transmission
• DNPI
• L-glutamate
• osteoblast
• secretory granule
• synaptic-like microvesicle
• synaptic vesicle
• vesicular glutamate transporter
• VGLUT

詳細情報

• CRID: 1390282679940637696
• NII論文ID: 130003534648
• NII論文ID: 10016197940
• NII書誌ID: AA00694073
• DOI: 10.1093/jb/mvh018
• COI: 1:CAS:528:DC%2BD2cXktV2hu74%3D
• ISSN: 17562651
• ISSN: 0021924X
• NDL書誌ID: 6887476
• PubMed: 15047716
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6887476
• Web Site: http://academic.oup.com/jb/article-pdf/135/2/155/2397834/mvh018.pdf
• Web Site: https://search.jamas.or.jp/link/ui/2004243829
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可