Abundant Retention and Release of Connective Tissue Growth Factor (CTGF/CCN2) by Platelets

• Kubota Satoshi

  Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry Biosciences Research & Development Center, Nichirei Corporation

• Kawata Kazumi

  Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry Biosciences Research & Development Center, Nichirei Corporation

• Yanagita Takeshi

  Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry Biosciences Research & Development Center, Nichirei Corporation

• Doi Hideyuki

  Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry Biosciences Research & Development Center, Nichirei Corporation

• Kitoh Takashi

  Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry Biosciences Research & Development Center, Nichirei Corporation

• Takigawa Masaharu

  Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine and Dentistry Biosciences Research & Development Center, Nichirei Corporation

抄録

Wound healing and tissue regeneration are usually initiated by coagulation followed by fibrous tissue formation. In the present study, we discovered an abundance of connective tissue growth factor (CTGF/CCN2) in human platelets, which was released along with the coagulation process. The CTGF/CCN2 content in platelets was 10-fold higher than that in arterial tissue. Furthermore, the CTGF/CCN2 content in a single platelet was computed to be more than 20-fold higher than that of any other growth factor reported. Considering that CTGF/CCN2 promotes angiogenesis, cartilage regeneration, fibrosis and platelet adhesion, it may be now regarded as one of the major functional components of platelets.

収録刊行物

• The Journal of Biochemistry

  The Journal of Biochemistry 136 (3), 279-282, 2004

  社団法人 日本生化学会

キーワード

• CCN2
• CTGF
• platelet
• tissue regeneration
• wound healing

詳細情報

• CRID: 1390282679942083584
• NII論文ID: 130003534720
• NII論文ID: 10016201865
• NII書誌ID: AA00694073
• DOI: 10.1093/jb/mvh126
• COI: 1:CAS:528:DC%2BD2cXhtFajtbzO
• ISSN: 17562651
• ISSN: 0021924X
• NDL書誌ID: 7129496
• PubMed: 15598883
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7129496
• Web Site: http://academic.oup.com/jb/article-pdf/136/3/279/2410856/mvh126.pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006073498
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可