口腔癌化学療法時における注射剤塩酸グラニセトロンと経口剤塩酸トロピセトロンの制吐効果の臨床的比較検討 [in Japanese] Clinical Comparative Study of Anti-emetic Effects of Granisetron Hydrochloride v. s. Tropisetron Hydrochloride capsule for Chemotherapy in Oral Cancer Patients [in Japanese]
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CDDP, commonly used to treat oral cancer, frequently induces adverse effects, such as severe anorexia, nausea, and emesis associated with chemotherapy. Recently, several 5-HT<SUB>3</SUB>receptor antagonists have developed, and among them, Granisetron hydrochrolide injection has been widely used so far. Tropisetron hydrochrolide, an oral anti-emetic reported to be as effective as parenteral anti-emetics, was launched Japan in 1998. Here, We report a comparison of the effectiveness between Kytril<SUP>®</SUP> infusion and Navoban<SUP>®</SUP> capsules, in terms of the grade of anorexia, nausea and emesis, measurement of Performance Status, and evaluation using a QOL questionnaire. Twenty oral cancer patients that received chemotherapy with CDDP and 5-FU were enrolled in the study. Our study clarified that oral anti-emetics exerted anti-anorectic, and anti-emetics effects as potently as parenteral drugs.
- ORAL THERAPEUTICS AND PHARMACOLOGY
ORAL THERAPEUTICS AND PHARMACOLOGY 19(2), 51-61, 2000-08-01
JAPANESE SOCIETY OF ORAL THERAPEUTICS AND PHARMACOLOGY