女性肺癌の臨床像  [in Japanese] Clinical Features of Female Lung Cancer  [in Japanese]

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Abstract

女性肺癌の臨床像について, とくに喫煙歴に注目して男性と比較検討した.女性の喫煙率は男性の1/3以下, 平均喫煙指数も1/2以下であった.女性では男性と比較して腺癌, 無自覚症状者, 臨床病期I期, IV期, PS0, 4が有意に多く, 検診発見者が多い傾向にあった.しかし, 喫煙歴別では, 非喫煙女性で非喫煙男性に比較してPS0が有意に多かったほかに男女間に有意差はなかった.また, 喫煙女性は非喫煙女性と比較し自覚症状発見者, 有自覚症状者が有意に多く, IV期, PS4が多い傾向にあった.予後は, 全症例およびおもな予後因子で層別しても男女間に有意差はなかったが, 腺癌のIV期では女性の予後が有意に良好であった.女性肺癌の臨床像の特徴は男性と比較して喫煙歴が少ないことによる影響が大きいと考えられた.また, 喫煙歴の有無は男性と比較して女性でより大きく臨床像に影響を与えていた.

A retrospective study of 104 women and 375 men with primary lung cancer was conducted to clarify sex-associated difference in clinical features, with special reference to smoking habits.The ratio of smokers and the smoking index in women were significantly lower than those in men, respectively.Adenocarcinoma was the most common histologic type in women.Women showed significantly fewer symptoms than men.The ratios of women who were diagnosed as clinical stage I or IV and performance status(PS)0or4were significantly higher than those of men, respectively.However, these sex-associated differences of clinical features were closely related to differences in smoking habits between both sexes.In this study, smoking women showed significantly more symptoms than non-smoking women.The ratios of smoking women who were diagnosed as clinical stage IV and PS 4 were significantly higher than those of non-smoking women, respectively.Smoking habits had more important effects on clinical features of lung cancer in women than in men.There were no sex-associated differences in the survival of all cases or in the survivals by histologic type, clinical stage, PS, treatment or smoking habits.However, the survival of women with stage IV adenocarcinoma was significantly better than that of men in the same group.There were no differences in clinical features, apart from smoking habits, between men and women with stage IV adenocarcinoma.

Journal

  • Japanese Journal of Lung Cancer

    Japanese Journal of Lung Cancer 36(6), 765-774, 1996-10-20

    The Japan Lung Cancer Society

References:  21

Cited by:  2

Codes

  • NII Article ID (NAID)
    10016260714
  • NII NACSIS-CAT ID (NCID)
    AN00203978
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03869628
  • Data Source
    CJP  CJPref  NII-ELS 
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