Molecular Cloning of Quail Thyroid-Stimulating Hormone (TSH) .BETA. Subunit.

DOI Web Site PubMed 被引用文献5件 参考文献16件
  • KATO YUKIO
    Biosignal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
  • KATO TAKAKO
    Biosignal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
  • TOMIZAWA KYOKO
    Biosignal Research Center, Institute for Molecular and Cellular Regulation, Gunma University
  • IWASAWA ATSUSHI
    Department of Animal Science and Technology, Faculty of Agriculture, Gifu University

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抄録

Thyroid-stimulating hormone (TSH) β subunit cDNA was obtained from Japanese quail (Coturnix japonica) by PCR and its nucleotide sequence was determined. The cDNA encodes a putative signal peptide and a mature protein consisting of 20 and 114 amino acids, respectively. The amino acid sequence of quail TSHβ subunit shows homologies of 67-69% in mammalian species, 58% in amphibian and 43-49% in teleost fish. Comparison of the amino acid sequence with TSHβ subunits of other species reveals some differences in several regions responsible for its biological functions and characteristic features of the avian TSHβ subunit, suggesting that the functional domains have diverged cooperatively between the hormone and its receptor during evolution.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 44 (6), 837-840, 1997

    一般社団法人 日本内分泌学会

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