Cognitive Decline in Patients with Long-Term Domiciliary Oxygen Therapy

DOI Web Site PubMed 参考文献27件
  • Ohrui Takashi
    Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine
  • Tanaka Kazunori
    Teijin Home Healthcare East Japan Limited
  • Chiba Kazue
    Teijin Home Healthcare East Japan Limited
  • Matsui Toshifumi
    Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine
  • Ebihara Satoru
    Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine
  • He Mei
    Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine
  • Tsuji Ichiro
    Division of Epidemiology, Department of Public Health, Tohoku University Graduate School of Medicine
  • Arai Hiroyuki
    Department of Geriatric and Complementary Medicine, Tohoku University Graduate School of Medicine
  • Sasaki Hidetada
    Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine

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Cognitive and psycho-physiological condition in patients with long-term domiciliary oxygen therapy (DOT) remains uncertain. A cross sectional analysis was performed to investigate the age-related changes in cognitive and psycho-physiologic functions in patients with chronic respiratory failure receiving long-term DOT. Two expert practitioners visited the patient's home and examined them for analysis of cognitive function, emotional status, physical activity and degree of dyspneic sensation. One hundred and thirty-five patients completed the study. Control data from a cohort of 718 community dwellers were also included in this study. Male patients had significantly higher rates of chronic obstructive pulmonary disease (71% vs 47%, p = 0.001), lower values of forced expiratory volume in one second (FEV1.0) % (49.7 ± 10.3 [standard deviation, S.D.] vs 66.0 ± 7.5% predicted, p = 0.002) and higher Borg score, an indicator of dyspneic sensation, during daily exercise (3.2 ± 0.8 [S.D.] vs 1.4 ± 0.6, p = 0.01) compared with female patients. Linear regression analysis based on mean Mini-Mental State Examination scores, an indicator of cognitive function, showed that age-related cognitive decline was more pronounced in female patients than in female controls (−0.524/year, R2 = 0.426 vs −0.120/year, R2 = 0.027, p < 0.0001), while there was no significant difference between male patients and male controls (−0.156/year, R2 = 0.054, vs −0.077/year, R2 = 0.016, p = 0.231). These results demonstrate that age-related cognitive decline is more exaggerated in female patients receiving long-term DOT which should be taken into consideration in caring for patients with chronic respiratory failure.

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