Quantitative Trait Loci for Glomerulosclerosis, Kidney Weight and Body Weight in the Focal Glomerulosclerosis Mouse Model

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  • KIM Eun-Hee
    Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University
  • LEE Chul-Ho
    Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
  • HYUN Byung-Hwa
    Genetic Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
  • SUH Jun-Gyo
    Department of Medical Genetics/Experimental Animal Center, College of Medicine, Hallym University
  • OH Yang-Seok
    Department of Medical Genetics/Experimental Animal Center, College of Medicine, Hallym University
  • NAMIKAWA Takao
    Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University
  • ISHIKAWA Akira
    Laboratory of Animal Genetics, Graduate School of Bioagricultural Sciences, Nagoya University

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Abstract

In 183 male progeny derived from a backcross between the FGS/Kist strain, a new mouse model for focal glomerulosclerosis (FGS) in humans, and the standard normal strain, C57BL/6J, we performed a genome-wide scan for quantitative trait loci (QTLs) affecting the glomerulosclerosis index (GSI) based on histological observation as well as kidney and body weights. Two QTLs for GSI (Gsi1-2) located on chromosomes (Chrs) 8 and 10, a kidney weight QTL (Kdw1) on Chr 19, and a body weight QTL (Bdw1) on Chr 13 were detected at the genome-wide 5% or less level. The allele derived from FGS/Kist increased GSI at Gsi1, but decreased it at Gsi2. The mice homozygous for the FGS/Kist allele decreased body and kidney weights. The identified QTLs accounted for 5-8% of the phenotypic variance.<br>

Journal

  • Experimental Animals

    Experimental Animals 54 (4), 319-325, 2005

    Japanese Association for Laboratory Animal Science

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