Immunosuppressive Sesquiterpenes from Tripterygium wilfordii

• Wang Xiaodong

  The College of Pharmaceuticals and Biotechnology, Tianjin University

• Gao Wenyuan

  The College of Pharmaceuticals and Biotechnology, Tianjin University

• Yao Zhi

  Department of Immunology, Tianjin Medical University

• Zhang Shaoyu

  The School of Pharmacy, Tianjin Medical University

• Zhang Yanwen

  The School of Pharmacy, Tianjin Medical University

• Takaishi Yoshihisa

  Faculty of Pharmaceutical Sciences, University of Tokushima

• Duan Hongquan

  The School of Pharmacy, Tianjin Medical University

Abstract

Five new sesquiterpenes, 1β-furanoyl-2β,3α,7α,8β,11-pentaacetoxy-4α,5α-dihydroxy-dihydroagarofuran (1), 1β,2β,3α,5α,7β,8β,11-heptaacetoxy-dihydroagarofuran (2), 1β-furanoyl-2β,3α,7α,8β,11-pentaacetoxy-5α-hydroxy-dihydroagarofuran (3), 1β,7β,8α-triacetoxy-2β-furanoyl-4α-hydroxy-11-isobutyryloxy-dihydroagarofuran (4), and 1β-nicotinoyl-2β,5α,7β-triacetoxy-4α-hydroxy-11-isobutyryloxy-8α-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2—5 showed significant immunosuppressive activities.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 53 (6), 607-610, 2005

  The Pharmaceutical Society of Japan

Keywords

• <i>Tripterygium wilfordii</i>
• xylem
• sesquiterpene
• immunosuppressive activity

Details

• CRID: 1390001204169107200
• NII Article ID: 10016654009
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.53.607
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 7318309
• PubMed: 15930767
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7318309
• Web Site: http://www.jstage.jst.go.jp/article/cpb/53/6/53_6_607/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed