Immunosuppressive Sesquiterpenes from Tripterygium wilfordii

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Author(s)

Abstract

Five new sesquiterpenes, 1β-furanoyl-2β, 3α, 7α, 8β, 11-pentaacetoxy-4α, 5α-dihydroxy-dihydroagarofuran (1), 1β, 2β, 3α, 5α, 7β, 8β, 11-heptaacetoxy-dihydroagarofuran (2), 1β-furanoyl-2β, 3α, 7α, 8β, 11-pentaacetoxy-5α-hydroxy-dihydroagarofuran (3), 1β, 7β, 8α-triacetoxy-2β-furanoyl-4α-hydroxy-11-isobutyryloxy-dihydroagarofuran (4), and 1β-nicotinoyl-2β, 5α, 7β-triacetoxy-4α-hydroxy-11-isobutyryloxy-8α-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2-5 showed significant immunosuppressive activities.

Journal

  • Chemical & pharmaceutical bulletin

    Chemical & pharmaceutical bulletin 53(6), 607-610, 2005-06-01

    The Pharmaceutical Society of Japan

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Codes

  • NII Article ID (NAID)
    10016654009
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00092363
  • NDL Article ID
    7318309
  • NDL Source Classification
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No.
    Z53-D167
  • Data Source
    CJP  NDL  NII-ELS  J-STAGE 
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