Humulene Derivatives from Zingiber zerumbet with the Inhibitory Effects on Lipopolysaccharide-Induced Nitric Oxide Production

• Jang Dae Sik

  Division of Molecular Life Sciences, Ewha Womans University Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine

• Min Hye-Young

  College of Pharmacy, Ewha Womans University

• Kim Moon-Sun

  College of Pharmacy, Ewha Womans University

• Han Ah-Reum

  College of Pharmacy, Ewha Womans University

• Windono Tri

  Faculty of Pharmacy, University of Surabaya

• Jeohn Gwang-Ho

  Faculty of Science, Brawijaya University

• Kang Sam Sik

  Natural Product Research Institute, Seoul National University, Korea

• Lee Sang Kook

  College of Pharmacy, Ewha Womans University

• Seo Eun-Kyoung

  College of Pharmacy, Ewha Womans University

抄録

A new humulene sesquiterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E-humulatrien-8-one) (1) and a known compound, zerumboneoxide (2) were isolated from the rhizomes of Zingiber zerumbet (Zingiberaceae), and found to inhibit lipopolysaccharide-induced nitric oxide production in murine macrophage RAW 264.7 cells with IC₅₀ values of 14.1 and 23.5 μM, respectively, by bioassay-guided fractionation (positive control: N^ω-monomethyl-L-arginine, IC₅₀=21.3 μM). The structure of 1 was determined by spectroscopic methods including 1D and 2D-NMR.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 53 (7), 829-831, 2005

  公益社団法人 日本薬学会

キーワード

• 5-hydroxyzerumbone
• zerumboneoxide
• <i>Zingiber zerumbet</i>
• nitric oxide production

詳細情報

• CRID: 1390282679147876352
• NII論文ID: 10016655190
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.53.829
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 7343372
• PubMed: 15997145
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7343372
• Web Site: http://www.jstage.jst.go.jp/article/cpb/53/7/53_7_829/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可