Synthesis and Triplex-Forming Ability of 2', 4'-BNAs Bearing Imidazoles as a Nucleobase

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Author(s)

Abstract

To expand the sequence of double-stranded DNA (dsDNA) targets in a triplex formation, 2',4'-BNAs (2'-O,4'-C-methylene bridged nucleic acids) having imidazoles as a nucleobase were synthesized and incorporated into oligonucleotides. Triplex-forming ability of the modified oligonucleotides was evaluated by using melting temperature (T_m) measurements.

Journal

  • Chemical & pharmaceutical bulletin

    Chemical & pharmaceutical bulletin 53(7), 843-846, 2005-07-01

    The Pharmaceutical Society of Japan

References:  21

Cited by:  1

Codes

  • NII Article ID (NAID)
    10016655278
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00092363
  • NDL Article ID
    7343406
  • NDL Source Classification
    ZS51(科学技術--薬学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No.
    Z53-D167
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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