Free Radical Scavenging and Hepatoprotective Actions of the Medicinal Herb, Crassocephalum crepidioides from the Okinawa Islands

• Aniya Yoko

  Laboratory of Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus

• Koyama Tomoyuki

  Laboratory of Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus

• Miyagi Chika

  Department of Laboratory Medicine, Faculty of Medicine, University of the Ryukyus

• Miyahira Manami

  Laboratory of Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus

• Inomata Chiho

  Laboratory of Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus

• Kinoshita Shizuka

  Laboratory of Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus

• Ichiba Toshio

  Okinawa Industrial Technology Center

抄録

Free radical scavenging and protective actions against chemically induced hepatotoxicity of Crassocephalum crepidioides were investigated. A water extract of C. crepidioides strongly scavenged superoxide anion, hydroxyl radical and also stable radical 1,1-diphenyl-2-picrylhydrazyl. Galactosamine (GalN, 400 mg/kg) and lipopolysaccharide (LPS, 0.5 μg/kg) induced hepatotoxicity of rats as seen by an elevation of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and of lipid peroxidation in liver homogenates was significantly depressed when the herbal extract was given intraperitoneally 1 and 15 h before GalN and LPS treatment. Similarly, carbon tetrachloride (CCl₄) induced liver injury as evidenced by an increase in AST and ALT activities in serum was also inhibited by the extract pretreatment. Isochlorogenic acids, quercetin and kaempferol glycosides were identified as active components of C. crepidioides with strong free radical scavenging action. These results demonstrate that C. crepidioides is a potent antioxidant and protective against GalN plus LPS- or CCl₄-induced hepatotoxicity.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 28 (1), 19-23, 2005

  公益社団法人 日本薬学会

キーワード

• natural antioxidant
• galactosamine
• carbon tetrachloride
• free radical
• medicinal herb

詳細情報

• CRID: 1390282679604511360
• NII論文ID: 10016658424
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.28.19
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7200840
• PubMed: 15635156
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7200840
• Web Site: http://www.jstage.jst.go.jp/article/bpb/28/1/28_1_19/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006233305
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可