ueda, N. and Naito, S.: Soybean oil fat emulsion prevents cytochrome P450 mRNA down-regulation induced by fat-free overdose total parenteral nutrition in infant rats

• Yamaguchi Mari

  Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc. Department of Pharmaceutical Information Science, Graduate School of Pharmacy, The University of Tokushima

• Yamauchi Aiko

  Department of Pharmaceutical Information Science, Graduate School of Pharmacy, The University of Tokushima

• Nishimura Masuhiro

  Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.

• Ueda Nobuhiko

  Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.

• Naito Shinsaku

  Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc.

書誌事項

タイトル別名

• Soybean Oil Fat Emulsion Prevents Cytochrome P450 mRNA Down-Regulation Induced by Fat-Free Overdose Total Parenteral Nutrition in Infant Rats
• Soybean oil fat emulsion prevents cytochrome P450 mRNA down­regulation induced by fat­free overdose total parenteral nutrition in infant rats

抄録

Changes in the mRNA expression of hepatic cytochrome P450 (CYP) isoenzymes associated with overdose of fat-free or fat-containing total parenteral nutrition (TPN) were investigated in infant rats. Three-week-old male Sprague–Dawley rats were divided into three groups: group 1 received an oral diet, group 2 received TPN without fat, and group 3 received TPN with 20% of calories from fat (soybean oil emulsion). After TPN administration for 4 d, serum aspartate aminotransferase (AST) levels in group 2 were significantly increased (p<0.01) compared with the other groups. The mRNA expression of hepatic CYP isoenzymes in group 2 decreased to 0.76 to 31% of that in group 1 (p<0.01), but that in group 3 was maintained at 32 to 84% of that in group 1. These results indicate the importance of including fat in TPN regimens to prevent not only hepatic dysfunction but also mRNA down-regulation of liver CYP isoenzymes.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 28 (1), 143-147, 2005

  公益社団法人 日本薬学会

キーワード

• mRNA expression
• fat emulsion
• cytochrome P450
• infant rat liver
• total parenteral nutrition

詳細情報

• CRID: 1390282679604529280
• NII論文ID: 10016659104
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.28.143
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7201347
• PubMed: 15635179
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7201347
• Web Site: http://www.jstage.jst.go.jp/article/bpb/28/1/28_1_143/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006233328
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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