Randomized Comparison of Cilostazol vs Ticlopidine for Antiplatelet Therapy After Coronary Stenting
-
- Takeyasu Noriyuki
- Cardiovascular Division, Department of Internal Medicine, Tsukuba Medical Center Hospital
-
- Watanabe Shigeyuki
- Medical Science for Control of Pathological Processes, Graduate School of Comprehensive Human Sciences, University of Tsukuba
-
- Noguchi Yuichi
- Cardiovascular Division, Department of Internal Medicine, Tsukuba Medical Center Hospital
-
- Ishikawa Kimito
- Cardiovascular Division, Department of Internal Medicine, Tsukuba Medical Center Hospital
-
- Fumikura Yuko
- Cardiovascular Division, Department of Internal Medicine, Tsukuba Medical Center Hospital
-
- Yamaguchi Iwao
- Medical Science for Control of Pathological Processes, Graduate School of Comprehensive Human Sciences, University of Tsukuba
この論文をさがす
抄録
Background Cilostazol and ticlopidine are commonly prescribed for prevention of thrombosis after coronary stenting, but few studies have compared them. Methods and Results In the present study 642 patients who underwent stenting were randomized to treatment either with cilostazol + aspirin (C group, 321 patients) or ticlopidine + aspirin (T group, 321 patients). Quantitative coronary angiography (QCA) was performed immediately after stenting and at the 6-month follow-up. Treatment was continued until follow-up angiography. Baseline patient characteristics did not differ significantly. With the exception of a higher rate of stenting in a venous graft in the C group, there were no differences in angiographic characteristics or stent type. Baseline QCA analysis of the reference diameter, minimal lumen diameter (MLD) showed no significant differences. Follow-up QCA analysis of the MLD showed no significant differences. There were also no differences in restenosis or target lesion revascularization rates, or in the incidence of adverse reactions. However, the rate of subacute thrombosis (SAT) was significantly higher in the C group than in the T group (2% vs 0.3%, p=0.02). Conclusion In the present study there was a similar restenosis rate with cilostazol or ticlopidine, but the rate of SAT was significantly higher with cilostazol. There was no significant difference in adverse reactions. (Circ J 2005; 69: 780 - 785)<br>
収録刊行物
-
- Circulation Journal
-
Circulation Journal 69 (7), 780-785, 2005
一般社団法人 日本循環器学会
- Tweet
詳細情報
-
- CRID
- 1390282680080619008
-
- NII論文ID
- 10016669017
-
- NII書誌ID
- AA11591968
-
- ISSN
- 13474820
- 13469843
-
- PubMed
- 15988102
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可