ヒトフローラ研究―現在と将来―

• 石橋 憲雄

  森永乳業 (株) 栄養科学研究所

• 山崎 省二

  国立保健医療科学院

書誌事項

タイトル別名

• Probiotics and Safety.
• プロバイオティクスの安全性について

抄録

Bacterial species that have traditionally been regarded as safe are used in probiotics. The main strains used include lactic acid bacteria and bifidobacteria. However, reports of frequent isolation of bacteria used in probiotics from infection sources in recent years have raised much debate over the safety of probiotics. This article describes the status quo of isolation of probiotic bacteria from infections and reviews each of the factors that have to be addressed in assessing the safety of probiotics, namely pathogenicity, infectivity, toxicity, and intrinsic properties of the bacteria. Monoassociation with Bifidobacterium longum BB536 in gnotobiotic mice as a method to assess safety with respect to infection, and translocation and immune responses as a result of the monoassociation are also described.

収録刊行物

• 腸内細菌学雑誌

  腸内細菌学雑誌 16 (2), 131-137, 2002

  公益財団法人 腸内細菌学会

キーワード

• probiotics
• safety
• infection
• translocation
• B. longum BB536

詳細情報

• CRID: 1390001204352994432
• NII論文ID: 10016674067
• NII論文ID: 10019042752
• NII論文ID: 80015546718
• NII書誌ID: AA11373504
• DOI: 10.11209/jim1997.16.131
• DOI: 10.11209/jim.19.179
• ISSN: 13498363
• ISSN: 13430882
• Web Site: https://search.jamas.or.jp/link/ui/2003088330
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可