甲状腺髄様癌術後肝転移に対し肝動脈化学塞栓療法が有効であった1例  [in Japanese] A CASE OF POSTOPERATIVE LIVER METASTASIS FROM MEDULLARY CARCINOMA OF THYROID TREATED WITH CHEMOEMBOLIZATION  [in Japanese]

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Abstract

甲状腺髄様癌術後の肝転移に対し肝動脈化学塞栓療法を施行し,以後2年間腫瘍マーカーの上昇なく病状コントロールできている症例を経験したので報告する.患者は女性. 14歳時に甲状腺髄様癌(pT2bN1bM0)にて甲状腺全摘術とD3a郭清を施行した. 17歳の頃からCEA,カルシトニン値が徐々に上昇したため種々の画像診断を行ったが再発,転移巣は明らかでなかった. 22歳時の造影CTで肝内に造影早期相で濃染する1.5cm大までの結節影を多数認め,腫瘍マーカーはCEA 852.9ng/ml,カルシトニン12,100pg/mlまで上昇していた.これらの病変に対し動脈化学塞栓療法を計3回施行した.以後2年経過するが肝の結節影に増大傾向は認めず,腫瘍マーカーはCEA 577.5ng/ml,カルシトニン6,400pg/mlとピーク時より低下したレベルで横ばいとなっており健在である.

We report a case of postoperative liver metastasis from medullary carcinoma of thyroid treated with chemoembolization which resulted in stable values of tumor markers for 2 yeas after the treatment.<br> The female patient underwent total thyroidectomy and lymphadenectomy (D3a) for medullary carcinoma of thyroid (pT2bN1bM0) of the age of 14. The values of serum CEA and calcitonin gradually increased at the age of 17, but various imaging examinations showed no recurrence or metastatic lesions. Eight years after the operation when she was 22, enhanced computed tomographic scan showed multiple metastatic lesions with the diameter of less than 1.5cm, which were enhanced in the early phase, of the liver. The value of serum CEA was 852.9ng/ml, and calcitonin was 12100pg/ml. We performed chemoembolization 3 times for these lesions. Though 2 years have elapsed afterward, no changes in the size or shape of the hepatic masses have been observed and the values of serum CEA and calcitonin remains relatively low (CEA: 577.5ng/ml and calcitonin: 6400pg/ml).

Journal

  • Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)

    Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 66(7), 1709-1712, 2005-07-25

    Japan Surgical Association

References:  16

Cited by:  1

Codes

  • NII Article ID (NAID)
    10016686890
  • NII NACSIS-CAT ID (NCID)
    AA11189709
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    13452843
  • Data Source
    CJP  CJPref  J-STAGE 
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