Sugar-Sensitive Thin Films Composed of Concanavalin A and Sugar-Bearing Polymers
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- SATO Katsuhiko
- Graduate School of Pharmaceutical Sciences, Tohoku University
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- KODAMA Daisuke
- Graduate School of Pharmaceutical Sciences, Tohoku University
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- ANZAI Jun-ichi
- Graduate School of Pharmaceutical Sciences, Tohoku University
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Layered thin films composed of concanavalin A (Con A) and sugar-bearing polymers were prepared by a layer-by-layer deposition of Con A and the polymer on a solid surface. The sugar-induced disintegration was studied. Con A-polymer layered films could be successfully prepared using a maltose-bearing polymer (PV-MA), while melibiose- and glucose-bearing polymers (PV-MEA and PV-G) did not afford a layered film, due to a weak affinity of PV-MEA and PV-G to Con A. The Con A/PV-MA layered film was stable in pH 7 and 8 solutions, while in a pH 6 medium the film was slightly unstable. The Con A/PV-MA film was disintegrated upon the addition of sugars in solution owing to a preferential binding of the sugars to the binding site of Con A in the film. The disintegration rate was dependent on the type of sugar and its concentration. The Con A/PV-MA film was disintegrated rapidly upon the addition of methyl α-D-mannopyranoside, while the rate was slower upon the addition of the same concentration of D-mannose, D-glucose and methyl α-D-glucopyranoside. The present system may be useful for constructing sensitive devices that can release a drug or other functional molecules in response to sugars.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 21 (11), 1375-1378, 2005
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204257100416
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- NII論文ID
- 10016775744
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- NII書誌ID
- AA10500785
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- COI
- 1:CAS:528:DC%2BD2MXhtlGmsr7F
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 7694040
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- PubMed
- 16317909
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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