Cyclosporin Treatment in Steroid-resistant and Acutely Exacerbated Interstitial Pneumonia

• HOMMA Sakae

  Department of Respiratory Medicine, Respiratory Center, Tokyo

• SAKAMOTO Susumu

  Department of Respiratory Medicine, Respiratory Center, Tokyo

• KAWABATA Masateru

  Department of Respiratory Medicine, Respiratory Center, Tokyo

• KISHI Kazuma

  Department of Respiratory Medicine, Respiratory Center, Tokyo

• TSUBOI Eiyasu

  Department of Respiratory Medicine, Respiratory Center, Tokyo

• MOTOI Noriko

  Department of Pathology, Toranomon Hospital, Tokyo

• YOSHIMURA Kunihiko

  Department of Respiratory Medicine, Respiratory Center, Tokyo

抄録

Objective The aim of this study was to evaluate the efficacy of cyclosporin A (CsA) in patients with interstitial pneumonia (IP).<br>Design Retrospective comparative study.<br>Patients We reviewed 33 patients (23 males and 10 females with a mean age of 62.5 years) with histologically-proven progressive IP who were treated with CsA. All patients had corticosteroid-resistant IP or developed acute exacerbation of IP in their courses.<br>Results The underlying systemic diseases were: idiopathic interstitial pneumonias (IIPs) in 19 patients, and collagen vascular diseases (CVDs) in 14. The histopathological patterns and underlying diseases of IP were classified as usual interstitial pneumonia (UIP)/idiopathic pulmonary fibrosis (IPF) in 10 patients, cellular-nonspecific interstitial pneumonia (NSIP)/IIPs in 3, fibrotic-NSIP/IIPs in 5, organizing pneumonia (OP)/IIP in 1, UIP/CVDs in 4, cellular-NSIP/CVDs in 7, fibrotic-NSIP/CVDs in 2, and diffuse alveolar damage (DAD)/CVD in 1, respectively. They received a low dosage of CsA combined with corticosteroids. The prognoses after treatment with CsA were well correlated with histopathological patterns. Cellular-NSIP and OP showed better prognoses than fibrotic-NSIP, UIP or DAD. In addition, CVDs had better prognoses than IIPs, when compared on the basis of the same histopathological patterns. Furthermore, the prognoses in the CsA-treated group were significantly better than in those without CsA treatment in regard to acute exacerbation of UIP/IPF.<br>Conclusions CsA combined with corticosteroids may be an efficacious treatment for corticosteroid-resistant IP and for acute exacerbation of IPF.

収録刊行物

• Internal Medicine

  Internal Medicine 44 (11), 1144-1150, 2005

  一般社団法人 日本内科学会

キーワード

• idiopathic interstitial pneumonia
• idiopathic pulmonary fibrosis
• interstitial pneumonia
• treatment
• cyclosporin
• survival rates

詳細情報

• CRID: 1390282679844233216
• NII論文ID: 10016885976
• NII書誌ID: AA10827774
• DOI: 10.2169/internalmedicine.44.1144
• COI: 1:STN:280:DC%2BD2MnmvFCgug%3D%3D
• ISSN: 13497235
• ISSN: 09182918
• NDL書誌ID: 7716126
• PubMed: 16357451
• Web Site: http://id.ndl.go.jp/bib/7716126
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7716126
• Web Site: http://www.jstage.jst.go.jp/article/internalmedicine/44/11/44_11_1144/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006295326
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可