ロドプシンの分子設計とその多様性

• 寺北 明久

  京都大学大学院理学研究科生物物理学教室 / JST・CREST

• 七田 芳則

  京都大学大学院理学研究科生物物理学教室 / JST・CREST

書誌事項

タイトル別名

• Molecular Architecture of Rhodopsin and Its Diversification
• ロドプシン ノ ブンシ セッケイ ト ソノ タヨウセイ

抄録

More than 1,000 rhodopsins and their related pigments (rhodopsins) have been identified thus far. The counterion, a negatively-charged amino acid residue which stabilizes a proton on the retinylidene Schiff base of the chromophore in rhodopsin is crucial for receiving a visible light. The mutational analyses by using the vertebrate and invertebrate rhodopsins revealed that counterion displacement from Glu181 to Glu113 had occurred during the molecular evolution of rhodopsins. Further biochemical analyses suggested that acquiring a new counterion Glu113 could be an essential replacement for not only emergence of efficient activation of G protein but also emergence of red-sensitive visual pigments.<br>

収録刊行物

• 生物物理

  生物物理 45 (6), 302-307, 2005

  一般社団法人 日本生物物理学会

キーワード

• rhodopsin
• visual pigment
• GPCR
• counterion
• G protein
• diversity

詳細情報

• CRID: 1390001206532234240
• NII論文ID: 10016895493
• NII書誌ID: AN00129693
• DOI: 10.2142/biophys.45.302
• ISSN: 13474219
• ISSN: 05824052
• NDL書誌ID: 7745371
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7745371
• Web Site: http://www.jstage.jst.go.jp/article/biophys/45/6/45_6_302/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006138348
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可