High Sensitivity and Large Dynamic Range Surface Plasmon Resonance Sensing for DNA Hybridization Using Au-Nanoparticle-Attached Probe DNA

• Hayashida Masayuki

  Research Institute for Electronic Science, Hokkaido University CREST-JST, Hokkaido University

• Yamaguchi Akira

  Department of Chemistry, Graduate School of Science, Tohoku University

• Misawa Hiroaki

  Research Institute for Electronic Science, Hokkaido University CREST-JST, Hokkaido University

抄録

In this study, we demonstrate the use of surface plasmon interaction between Au nanoparticles (GPs) and a Au thin film for enhancement of surface plasmon resonance (SPR) spectroscopy sensing for DNA hybridization. In situ DNA hybridization with a Au-nanoparticle-attached probe DNA (DNA-GP) monolayer is monitored by SPR spectroscopy, and the results reveal that the DNA-GP allows detection of unlabeled target DNA with the large dynamic range of 1 pM to 10 μM.

収録刊行物

• Japanese Journal of Applied Physics

  Japanese Journal of Applied Physics 44 (50-52), L1544-L1546, 2005

  The Japan Society of Applied Physics

キーワード

• Au nanoparticle
• DNA hybridization
• SPR
• label-free
• <I>in situ</I>

詳細情報

• CRID: 1390001206268766976
• NII論文ID: 10016920618
• NII論文ID: 130004533872
• NII論文ID: 210000059434
• NII書誌ID: AA11906093
• DOI: 10.1143/jjap.44.l1544
• ISSN: 13474065
• ISSN: 00214922
• NDL書誌ID: 7755899
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7755899
• Web Site: https://iopscience.iop.org/article/10.1143/JJAP.44.L1544
• Web Site: https://iopscience.iop.org/article/10.1143/JJAP.44.L1544/pdf
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可