Ｐｓｅｕｄｏｍｏｎａｓ　ａｅｒｕｇｉｎｏｓａに対するカルバペネム系抗菌薬間の抗菌作用の比較

• 島内 千恵子

  北里大学大学院医療系研究科環境感染学

• 兼子 謙一

  北里大学大学院医療系研究科環境感染学

• 佐藤 義則

  北里大学大学院医療系研究科環境感染学

• 佐藤 優子

  北里大学医学部微生物学

• 岡本 了一

  北里大学大学院医療系研究科環境感染学 北里大学医学部微生物学

• 井上 松久

  北里大学大学院医療系研究科環境感染学

書誌事項

タイトル別名

• Comparative basic study of carbapenems antibiotics against Pseudomonas aeruginosa

抄録

Carbapenems antibiotics [imipenem/cilastatin (IPM/CS), meropenem (MEPM), biapenem (BIPM) and doripenem (DRPM)] were compared in terms of their antimicrobial activity against Pseudomonas aeruginosa, their growth inhibition ring during incubation, their bactericidal effect in the presence or absence of serum, morphological changes, their binding affinity to penicillin-binding proteins (PBPs), and the influence of human serum and the inducibility of AmpC β-lactamase. The MIC₅₀ and MIC₉₀ values of IPM/CS, MEPM, BIPM and DRPM against 50 strains of P. aeruginosa clinically isolated in 2003 were 2 and 16, 1 and 16, 1 and 16 and 1 and 8 7mu;g/mL, respectively. The 1-hour bactericidal activity of carbapenem antibiotics that did not induce the formation of a double inhibition ring (IPM/CS and BIPM) was stronger than that of the drugs that induced a double ring formation (MEPM and DRPM). At the MIC of each drug, the bactericidal effect of IPM/CS and BIPM increased in the presence of human serum, but no increase was observed for MEPM or DRPM. This bactericidal activity was well reflected in the microbial conglobation (spherical forms) and bacteriolytic images observed in association with IPM/CS and BIPM. On the other hand, numerous microbes became filamentous after treatment with DRPM and MEPM, but no bacteriolytic images were seen. IPM/CS and BIPM exhibited the strongest binding affinity for PBP4, followed by 2, 1A÷3 and 1B. MEPM exhibited the strongest binding affinity for PBP4, followed by 3, 2, and 1A÷1B, and DRPM showed the strongest affinity for PBP4, followed by 3, 2, 1A and 1B. From the aspect of enzyme inducibility strong activity was observed for IPM/CS and BIPM, compared with MEPM and DRPM. These findings suggested that carbapenem antibiotics can be divided into two types: those with a strong bactericidal activity (IPM/CS, BIPM and perhaps panipenem) and those with a weak bactericidal activity (MEPM and DRPM).

収録刊行物

• 日本化学療法学会雑誌

  日本化学療法学会雑誌 53 (12), 732-740, 2005

  公益社団法人 日本化学療法学会

キーワード

• Pseudomonas aerugirtosa
• carbapenem
• penicillin binding proteins
• class C β-lactamase
• inducibility

詳細情報

• CRID: 1390282681261614336
• NII論文ID: 130004298241
• NII論文ID: 10016943187
• NII書誌ID: AN10472127
• DOI: 10.11250/chemotherapy1995.53.732
• ISSN: 18845886
• ISSN: 13407007
• Web Site: https://search.jamas.or.jp/link/ui/2006104973
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可