慢性放射線皮膚炎に多発性基底細胞癌と脂腺癌およびＭｉｃｒｏｃｙｓｔｉｃ　ａｄｎｅｘａｌ　ｃａｒｃｉｎｏｍａを生じた１例

DOI 被引用文献2件 参考文献9件

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  • A case of development of multiple basal cell cancer, sebaceous gland carcinoma and Microcystic adnexal carcinoma in chronic actinodermatitis.

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A 65-year-old Japanese man presented with an asymptomatic nodule of 3-month history on the right side of the nose. He had received radiation therapy for hemangioma of the nose when he was 17 years old. On physical examinasion, the nodule was dome shaped, dark-red colored and 15mm in size. Multiple black nodules varying from 1 to 3mm in size were also scattered on the poikilodermatous skin of his cheek and nose. In addition, an indurated plaque, 10 mm in size, was detected on the right nostril. Histopathologically, the nodule showed solid nests composed of atypical basaloid cells and foamy-vacuolated cells. The black nodules were revealed to be basal cell carcinoma. In the plaque lesion of the nostril, multiple discrete nests were found in the entire dermis and subcutis. The nests were partly continuous with the epidermal keratinocyte, and composed of atypical squamoid and basaloid cells with small keratinous cysts in the upper part. Interestingly, the neoplastic cells composing the discrete nests in the lower dermis showed vacuolated cytoplasm, indicating sebaceous differentiation.

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