Antitumor Protein Therapy; Application of the Protein Transduction Domain to the Development of a Protein Drug for Cancer Treatment

DOI Web Site 被引用文献2件 参考文献125件
  • Harada Hiroshi
    Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine Kyoto City Collaboration of Regional Entities for the Advancement of Technological Excellence, Japan Science and Technology Agency
  • Kizaka-Kondoh Shinae
    Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine COE formation for genomic analysis of disease model animals with multiple genetic alterations, Kyoto University Graduate School of Medicine
  • Hiraoka Masahiro
    Department of Radiation Oncology and Image-applied Therapy, Kyoto University Graduate School of Medicine

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抄録

The genomic information obtained through the human genome project has been accelerating the analysis of the functions of various disease relevant genes. The high molecular weight biomolecules, including oligonucleotides, antisense nucleotides, small interference RNA and peptides, as well as genes (cDNA) and proteins, are becoming increasingly important for the development of molecular therapies. However, the potential of such information-rich macromolecules for therapeutic use has been limited by the poor permeability across the lipid bilayer of the cellular plasma membrane. Over the past decade, a unique activity of oligopeptides, known as protein transduction domains (PTDs) or cell penetrating peptides (CPPs), has made it possible to transduce biologically active macromolecules into living cells in vitro by conjugating a PTD to the desired macromolecule. Furthermore, this activity has also enabled the systemic delivery of bioactive macromolecules to all tissues in living animals. However, we are now confronted with the next difficulty delivering the macromolecules specifically to the therapeutic targets in vivo. In this review, we focus on the application of PTD to develop antitumor macromolecules and introduce several representative strategies to discriminate between tumor and normal tissue. In addition, we discuss the unique characteristics of breast cancer, which are expected to facilitate the application of PTD to develop novel protein therapy for breast cancer.

収録刊行物

  • Breast Cancer

    Breast Cancer 13 (1), 16-26, 2006

    日本乳癌学会

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