環境カドミウム曝露による腎影響評価：富山県神通川流域の４５～５６歳男女住民を対象とした２０００‐２００２年調査成績

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  • Renal Effects of Environmental Exposure to Cadmium in Middle-Aged Population of Jinzu River Basin in Toyama, Japan: 2000-2002 Study
  • カンキョウ カドミウム バクロ ニ ヨル ジンエイキョウ ヒョウカ トヤマケン ジンツウガワ リュウイキ ノ 45 56サイ ダンジョ ジュウミン オ タイショウ ト シタ 2000 2002ネン チョウサ セイセキ
  • 2000-2002 Study
  • 富山県神通川流域の45∼56歳男女住民を対象とした2000-2002年調査成績

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Objective: In 2000-2002, the effects of environmental cadmium (Cd) exposure on renal tubular function were investigated in men and women born between January 1, 1946 and December 31, 1955, and living in the Cd-polluted Jinzu River basin in Toyama. It is assumed that these generations had been exposed to Cd mainly through the consumption of rice and vegetables grown locally, in contrast to older generations who had been exposed not only through the consumption of rice but also by drinking river water polluted with Cd discharged from a mine.<br>Methods: Morning urine specimens, self-administered questionnaires and polished rice samples consumed daily were collected from 110 men and 121 women living in the polluted area and from 48 men and 45 women living in the reference area.<br>Results: Urinary Cd excretion level, an indicator of Cd accumulation in the kidneys, significantly increased with increased duration (years) of residence in the Cd-polluted area in both men and women. There was no case of urinary β2-microglobulin (β2-MG) level exceeding 1, 000μg/g Cr in either sex, in contrast to the high prevalence of β2-MGuria observed in older generations. However, urinary β2-MG and α1-MG levels were slightly but significantly increased with increased duration (years) of residence in the Cd-polluted area in women.<br>Conclusions: The results indicate that men and women born between 1946 and 1955 and living in the Cd-polluted Jinzu River basin had Cd accumulation in the kidneys and a slight increase in urinary lowmolecular weight protein level due to this accumulation.

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