Renal Effects of Environmental Exposure to Cadmium in Middle-Aged Population of Jinzu River Basin in Toyama, Japan: 2000-2002 Study

• AOSHIMA Keiko

  Hagino Hospital

• KATOH Terutaka

  Department of Public Health, Faculty of Medicine, University of Toyama

• KASUYA Minoru

  Japan Labor Health and Welfare Organization, Toyama Occupational Health Promotion Center

Bibliographic Information

Other Title

• 環境カドミウム曝露による腎影響評価：富山県神通川流域の４５～５６歳男女住民を対象とした２０００‐２００２年調査成績
• カンキョウ カドミウム バクロ ニ ヨル ジンエイキョウ ヒョウカ トヤマケン ジンツウガワ リュウイキ ノ 45 56サイ ダンジョ ジュウミン オ タイショウ ト シタ 2000 2002ネン チョウサ セイセキ
• 2000-2002 Study
• 富山県神通川流域の45∼56歳男女住民を対象とした2000-2002年調査成績

Abstract

Objective: In 2000-2002, the effects of environmental cadmium (Cd) exposure on renal tubular function were investigated in men and women born between January 1, 1946 and December 31, 1955, and living in the Cd-polluted Jinzu River basin in Toyama. It is assumed that these generations had been exposed to Cd mainly through the consumption of rice and vegetables grown locally, in contrast to older generations who had been exposed not only through the consumption of rice but also by drinking river water polluted with Cd discharged from a mine.<br>Methods: Morning urine specimens, self-administered questionnaires and polished rice samples consumed daily were collected from 110 men and 121 women living in the polluted area and from 48 men and 45 women living in the reference area.<br>Results: Urinary Cd excretion level, an indicator of Cd accumulation in the kidneys, significantly increased with increased duration (years) of residence in the Cd-polluted area in both men and women. There was no case of urinary β₂-microglobulin (β₂-MG) level exceeding 1, 000μg/g Cr in either sex, in contrast to the high prevalence of β₂-MGuria observed in older generations. However, urinary β₂-MG and α₁-MG levels were slightly but significantly increased with increased duration (years) of residence in the Cd-polluted area in women.<br>Conclusions: The results indicate that men and women born between 1946 and 1955 and living in the Cd-polluted Jinzu River basin had Cd accumulation in the kidneys and a slight increase in urinary lowmolecular weight protein level due to this accumulation.

Journal

• Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

  Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) 61 (1), 69-80, 2006

  The Japanese Society for Hygiene

Keywords

• cadmium
• renal tubular dysfunction
• environmental exposure
• β₂-microglobulin
• Itai-itai disease

Details

• CRID: 1390282681339627392
• NII Article ID: 10017241028
• NII Book ID: AN00185923
• DOI: 10.1265/jjh.61.69
• ISSN: 18826482
• ISSN: 00215082
• NDL BIB ID: 7831184
• PubMed: 16506657
• Web Site: http://id.ndl.go.jp/bib/7831184
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7831184
• Web Site: http://www.jstage.jst.go.jp/article/jjh1946/61/1/61_1_69/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006140742
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed