微生物の病原性，宿主防御，炎症におけるＳｙｎｄｅｃａｎ‐１

DOI Web Site 参考文献46件
  • Park Pyong Woo
    Department of Medicine, Baylor College of Medicine Department of Molecular and Cellular Biology, Baylor College of Medicine Department of Molecular Virology and Microbiology, Baylor College of Medicine
  • Hayashida Atsuko
    Department of Medicine, Baylor College of Medicine
  • 吉崎 史子
    順天堂大学環境医学研究所
  • 中山 仁志
    順天堂大学環境医学研究所

書誌事項

タイトル別名
  • Syndecan-1 in Microbial Pathogenesis, Host Defense, and Inflammation
  • ビセイブツ ノ ビョウゲンセイ シュクシュ ボウギョ エンショウ ニ オケル Syndecan 1 ガン エイブン

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The epithelium plays a vital role in regulating tissue injury and inflammation because it frequently encounters and detects harmful agents that can initiate the inflammatory host response. The epithelium also elaborates cytokines, antimicrobial factors, proteinases, and other key inflammatory mediators, and regulates the recruitment of inflammatory cells to sites of tissue injury. Syndecan-1 is a major cell surface heparan sulfate proteoglycan of the epithelium that can bind and regulate many inflammatory factors through its heparan sulfate chains. Syndecan-1 expression and its secretion into the extracellular milieu by ectodomain shedding are regulated by various inflammatory mediators and pathological conditions. Recent data indicate that syndecan-1 protects the host from various non-infectious inflammatory disorders by coordinating epithelial cell proliferation and migration, neutralizing chemokines, attenuating exaggerated T lymphocyte homing, and by confining neutrophil migration to specific sites of tissue injury. However, several pathogens have devised schemes to take advantage of syndecan-1 to promote their pathogenesis. These findings indicate that syndecan-1 is a key molecule that modulates host responses to tissue injury in normal repair and in the pathogenesis of inflammatory diseases.

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