Poly(MPC-co-BMA) Coating Reduces the Adhesion of Candida albicans to Poly(Methyl Methacrylate) Surfaces

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Author(s)

    • HATSUNO Kunito
    • Department of Maxillofacial Prosthetics, Graduate School, Tokyo Medical and Dental University
    • MUKOHYAMA Hitoshi
    • Department of Maxillofacial Prosthetics, Graduate School, Tokyo Medical and Dental University
    • HORIUCHI Sankichi
    • Department of Molecular Virology, Bio-Response, Graduate School, Tokyo Medical and Dental University
    • IWASAKI Yasuhiko
    • Department of Organic Materials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
    • YAMAMOTO Naoki
    • Department of Molecular Virology, Bio-Response, Graduate School, Tokyo Medical and Dental University
    • AKIYOSHI Kazunari
    • Department of Organic Materials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
    • TANIGUCHI Hisashi
    • Department of Maxillofacial Prosthetics, Graduate School, Tokyo Medical and Dental University

Abstract

<b>Purpose:</b> The aim of the present study was to develop a new and simple method using PMB to prevent plaque colonization on denture surfaces.<br><b>Methods:</b> PMB polymerized with MPC polymer and BMA was prepared as a coating material. Water-insoluble PMB composed of 30 mol% MPC units (PMB30), water-soluble PMB composed of 80 mol% MPC units (PMB80) and clear PMMA disks were prepared. The PMMA disks were dip-coated in 0.5 wt% PMB30 solution or 0.5 wt% PMB80 solution. To examine the PMB coatings' durability, the PMB-coated disks were immersed in distilled water. The PMB elution ratio was measured using a phosphorus analysis. To evaluate the effect of the PMB coating on <i>Candida albicans</i> (<i>C. albicance</i>) adhesion, PMB-coated and uncoated disks were cultured in a solution containing <i>C. albicans</i> for 48 hours. Half of the disks in each group were not washed, and the remaining disks were washed with distilled water to examine the effect of washing. All the PMMA disks were observed and photographed, and the resulting images were analyzed using imaging analysis software.<br><b>Results:</b> In the first 48 hours, approximate 14 % of the PMB30-coating and 12 % of the PMB80-coating were eluted into the distilled water. The adhesion of <i>C. albicans</i> to the PMB30-coated or the PMB80-coated PMMA disks was significantly reduced in both the washed and unwashed groups, compared with the uncoated control disks.<br><b>Conclusion:</b> PMB coating prevents the adhesion of <i>C. albicans</i> to PMMA.

Journal

  • Prosthodontic Research & Practice

    Prosthodontic Research & Practice 5(1), 21-25, 2006-01-01

    Japan Prosthodontic Society

References:  21

Cited by:  1

Codes

  • NII Article ID (NAID)
    10017242308
  • NII NACSIS-CAT ID (NCID)
    AA11728086
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13477021
  • Data Source
    CJP  CJPref  J-STAGE 
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