DjlA negatively regulates the Rcs signal transduction system in Escherichia coli
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- Shiba Yasuhiro
- Department of Biochemistry and Molecular Biology, Faculty of Science, Saitama University
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- Matsumoto Kouji
- Department of Biochemistry and Molecular Biology, Faculty of Science, Saitama University
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- Hara Hiroshi
- Department of Biochemistry and Molecular Biology, Faculty of Science, Saitama University
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Abstract
The Rcs signal transduction system of Escherichia coli regulating capsular polysaccharide synthesis (cps) genes is activated by overexpression of the djlA gene encoding a cytoplasmic membrane-anchored DnaJ-like protein. However, by monitoring the expression of a cpsB’-lac fusion in pgsA- and mdoH-null mutants in which the Rcs system is activated, we found that the Rcs activity was further increased by deletion of djlA and decreased by low-level extrachromosomal expression of djlA. Furthermore, deletion of djlA in a wild-type strain led to small but significant increase of the basal-level activity of the Rcs system. These results demonstrate that DjlA functions as a negative regulator of the Rcs system unless abnormally overproduced.<br>
Journal
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- Genes & Genetic Systems
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Genes & Genetic Systems 81 (1), 51-56, 2006
The Genetics Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282680450402176
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- NII Article ID
- 10017408222
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- NII Book ID
- AA11077421
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- ISSN
- 18805779
- 13417568
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- NDL BIB ID
- 7882451
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed