腹腔鏡下胆嚢摘出術中における酸化ストレス指標としての尿中８‐ヒドロキシデオキシグアニジン（８‐ＯＨ‐ｄＧ）の推移

• 金田 徹

  静岡赤十字病院麻酔科

• 関 博志

  静岡赤十字病院麻酔科

• 勝又 澄

  静岡赤十字病院麻酔科

書誌事項

タイトル別名

• Change of urinary 8-hydroxydeoxyguanosine (8-OH-dG) value as a biomarker for oxidative stress during laparoscopic cholecystectomy

抄録

8-hydroxydeoxyguanosine (8-OH-dG) which is producted by oxidative DNA damage is one of the predominant forms of radical-induced lesion to DNA, and has been widely used as a biomarker for oxidative stress. To determine the relationship between oxidative DNA damage and surgical stress undergoing laparoscopic cholecystectomy (Lap-C) with Propofol (Target controlled infusion) and epidural anesthesia, we measured urinary 8-OH-dG using CoulArray Medical System (ESA Inc., USA) in 5 patients. The measurement points of 8-OH-dG were after induction of anesthesia, 5 min. after pneumoperitoneum, 30 min. after pneumoperitoneum, at the end of operation and next morning.Our results showed large intra-individual variation of urinary 8-OH-dG. Under influence of intraperitoneal infusion of CO₂, there is no change in urinary 8-OH-dG value. In our 5 cases, changes of urinary 8-OH-dG showed almost same pattern in all of the measurement point. From these results, it is thought that oxidative DNA damage during Lap-C is small or not. Still more, adequate depth of anesthesia may decrease oxidative stress caused by surgical stress during Lap-C. We suggest that adequate depth of anesthesia may have anti-oxidative effects.

収録刊行物

• 蘇生

  蘇生 25 (1), 12-16, 2006

  日本蘇生学会

キーワード

• 8-ヒドロキシデオキシグアニジン (8-OH-dG)
• 酸化的DNA損傷
• 手術侵襲
• 腹腔鏡下胆嚢摘出術

詳細情報

• CRID: 1390282681434892416
• NII論文ID: 130004019630
• NII論文ID: 10017417849
• NII書誌ID: AN10043787
• DOI: 10.11414/jjreanimatology1983.25.12
• ISSN: 1884748X
• ISSN: 02884348
• Web Site: https://search.jamas.or.jp/link/ui/2006125342
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可