DAILY CONCURRENT CHEMORADIOTHERAPY WITH DOCETAXEL (DOC) AND CISPLATIN (CDDP) USING SUPERSELECTIVE INTRA-ARTERIAL INFUSION VIA THE SUPERFICIAL TEMPORAL ARTERY FOR STAGE III AND IV ORAL CANCER-POSSIBILITY OF ORGAN PRESERVATION IN ADVANCED ORAL CANCER-

• MITSUDO Kenji

  Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

• TOHNAI Iwai

  Department of Cell Therapy, Nagoya University School of Medicine

• FUWA Nobukazu

  Department of Radiation Oncology, Aichi Cancer Center Hospital

• FURUTANI Kazuhisa

  Department of Radiation Oncology, Aichi Cancer Center Hospital

• NISHIGUCHI Hiroaki

  Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

• FUKUI Takafumi

  Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

• YAMAMOTO Noriyuki

  Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

• SUGIMURA Tomotaka

  Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

• SAITO Masaki

  Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

• UEDA Minoru

  Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine

Bibliographic Information

Other Title

• 浅側頭動脈よりの超選択的動注法を用いた連日同時放射線化学療法―Ｓｔａｇｅ　ＩＩＩ，ＩＶ口腔癌に対する原発巣温存の可能性について―
• —POSSIBILITY OF ORGAN PRESERVATION IN ADVANCED ORAL CANCER—
• ―Stage III，IV口腔癌に対する原発巣温存の可能性について―

Abstract

Superselective intra-arterial chemotherapy via the superficial temporal artery has become feasible for daily concurrent radiotherapy and chemotherapy for head and neck cancer. This novel method was used for oral cancer, and its efficacy was evaluated. Treatment consisted of superselective intra-arterial infusions (DOC total 60 mg/m², CDDP total 100 mg/m²) and concurrent radiotherapy (total 40 Gy) for four weeks as preoperative therapy. Thirty-four patients with stage III and IV oral cancer received surgery after this treatment, and pathological CR was obtained in 31 patients (91%). The possibility of organ preservation for advanced oral cancer was evaluated from this result. Patients with oral cancer stage III and IV were treated for four-week daily concurrent chemoradiotherapy, and the clinical response was evaluated after treatment. Clinical CR of primary sites was obtained in 15 patients, and the same treatment was continued one or two weeks. Thirteen patients (80%) were disease-free in the primary sites, and two (20%) relapsed. Two patients died of distant metastasis, and one died of local recurrence. This method can preserve organs and minimize functional disturbance, thus contributing to patient QOL.

Journal

• Toukeibu Gan

  Toukeibu Gan 32 (1), 93-97, 2006

  Japan Society for Head and Neck Cancer

Keywords

• oral cancer
• superselective intra-arterial infusion
• organ preservation
• survival rate
• chemoradiotherapy

Details

• CRID: 1390001205223553664
• NII Article ID: 10017419054
• NII Book ID: AA11985555
• DOI: 10.5981/jjhnc.32.93
• ISSN: 18818382
• ISSN: 13495747
• ISSN: http://id.crossref.org/issn/13495747
• Web Site: https://search.jamas.or.jp/link/ui/2006209386
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed