SUPERSELECTIVE INTRAARTERIAL CHEMOTHERAPY USING PERCUTANEOUS PUNCTURE OF THE SUPEERFICIAL TEMPORAL ARTERY FOR ADVANCED HEAD AND NECK CANCERS

• YANE Katsunari

  Departments of Otolaryngology, Nara Medical University

• YAMANAKA Toshiaki

  Departments of Otolaryngology, Nara Medical University

• OKAMOTO Hideyuki

  Departments of Otolaryngology, Nara Medical University

• MURAI Takayuki

  Departments of Otolaryngology, Nara Medical University

• FUKUDA Takehiko

  Departments of Otolaryngology, Nara Medical University

• NISHIMURA Tadayuki

  Departments of Otolaryngology, Nara Medical University

• KAMIJYO Tomoyuki

  Departments of Otolaryngology, Nara Medical University

• HOSOI Hiroshi

  Departments of Otolaryngology, Nara Medical University

• NAKAGAWA Hiroyuki

  Departments of Radiology, Nara Medical University

• FUWA Nobukazu

  Department of Radiotherapy, Aichi Cancer Center Hospital

Bibliographic Information

Other Title

• 経皮的動脈穿刺法による浅側頭動脈を用いた超選択的動注療法

Abstract

Superselective intraarterial chemotherapy for advanced head and neck cancers is a novel nonsurgical approach allowing organ preservation. There are two established methods for superselective catheterization: one transfemoral and the other retrograde catheterization through the superficial temporal artery (STA). The Seldinger technique using transfemoral catheterization may cause central nervous dysfunction and generally features a one-shot infusion procedure. However, selective catheterization through the STA does not cause neurologic problems, and intraarterial infusion can be repeated many times. After the percutaneous puncture of the STA in the supra-anterior region of the auricle, the guidewire is led selectively into the feeding artery of the tumor under fluoroscopic guidance, and then it is replaced with the infusion catheter. Recently, cisplatin (CDDP) has been recommended as a key drug for intraarterial chemotherapy, and weekly infusions of relatively low doses can be applied together with simultaneous intravenous sodium thiosulfate for systemic drug neutralization, or concurrent radiotherapy. This superselective intraarterial method is associated with a high response rate for primary carcinomas, only relatively mild systemic side effects, and acceptable common local toxicity. We consider that a combination of superselective intraarterial chemotherapy through the STA and concurrent radiotherapy has great potential for improving treatment results with organ preservation.

Journal

• Toukeibu Gan

  Toukeibu Gan 32 (1), 98-104, 2006

  Japan Society for Head and Neck Cancer

Keywords

• head and neck cancer
• superselective intra-arterial chemotherapy
• superficial temporal artery
• chemoradiation
• cisplatin

Details

• CRID: 1390001205223559296
• NII Article ID: 10017419068
• NII Book ID: AA11985555
• DOI: 10.5981/jjhnc.32.98
• ISSN: 18818382
• ISSN: 13495747
• ISSN: http://id.crossref.org/issn/13495747
• Web Site: https://search.jamas.or.jp/link/ui/2006209387
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed