Endogenous Uremic Substances are not Involved in the Reduced Hepatic Extraction of Metoprolol in Bilateral Ureter-Ligated Rats†
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- TAGUCHI Masato
- Graduate School of Pharmaceutical Sciences, University of Toyama
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- URAI Misato
- Graduate School of Pharmaceutical Sciences, University of Toyama
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- TAIRA Shigehiro
- Graduate School of Pharmaceutical Sciences, University of Toyama
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- TANABE Hiroko
- Graduate School of Pharmaceutical Sciences, University of Toyama
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- HASHIMOTO Yukiya
- Graduate School of Pharmaceutical Sciences, University of Toyama
書誌事項
- タイトル別名
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- Endogenous Uremic Substances are not Involved in the Reduced Hepatic Extraction of Metoprolol in Bilateral Ureter-Ligated Rats
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抄録
The hepatic extraction of metoprolol is reduced in rats with bilateral ureter ligation (BUL)-induced renal failure. The aim of the present study was to evaluate the effect of uremic substances on the hepatic metabolism of metoprolol in rats with BUL. The metabolic rate in the liver microsomes of BUL rats was similar to that in sham rats, and there was no significant difference between sham and BUL rats in the effect of the supernatant of liver homogenates on the metabolism. The rate of metabolism in the liver microsomes in the presence of the plasma of BUL rats was also similar to that in the presence of the plasma of sham rats. These findings indicated that uremic substances which accumulate in BUL rats do not directly inhibit the activity of CYP2D2, which is responsible for the metabolism of metoprolol in the rat liver.<br>
収録刊行物
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- Drug Metabolism and Pharmacokinetics
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Drug Metabolism and Pharmacokinetics 21 (2), 156-164, 2006
日本薬物動態学会
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詳細情報 詳細情報について
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- CRID
- 1390001205181420544
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- NII論文ID
- 10017423285
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- NII書誌ID
- AA1162652X
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- ISSN
- 18800920
- 13474367
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可